First consultation?
Need a refill?
First consultation?
Need a refill?
Enclomiphene Citrate: Everything You Need to Know
Enclomiphene Citrate
Eileen Quinones
•
6 mins
• Nov 26, 2024
Enclomiphene Citrate is gaining recognition as an effective treatment for male infertility and low testosterone levels, particularly in men suffering from secondary hypogonadism. Unlike traditional testosterone replacement therapy, which introduces external hormones into the body, Enclomiphene works by stimulating the body’s natural testosterone production. This makes it an attractive option for men seeking to preserve fertility while addressing hormonal imbalances.
In this article, we will explore how Enclomiphene Citrate works, its therapeutic uses, the administration and dosage guidelines, as well as potential side effects. Whether you're dealing with male infertility, low testosterone, or secondary hypogonadism, Enclomiphene offers a unique, non-steroidal alternative to conventional treatments. Keep reading to learn more about how this medication can help restore your hormonal health and overall well-being.
What is Enclomiphene Citrate?
Enclomiphene Citrate is a selective estrogen receptor modulator (SERM) similar to Clomiphene Citrate, commonly known for treating male infertility. Specifically, it helps men with low testosterone due to hypogonadotropic hypogonadism—a condition where the brain’s hypothalamus or pituitary gland doesn’t stimulate testosterone production effectively. This non-steroidal medication, part of the SERM family, encourages testosterone production naturally, preserving fertility while boosting hormone levels.
How Does Enclomiphene Citrate Work?
Enclomiphene works by blocking estrogen’s effects in the brain, stimulating the hypothalamic-pituitary-gonadal (HPG) axis. When estrogen levels are high, the hypothalamus and pituitary gland reduce the hormones that encourage testosterone production. Enclomiphene interferes with this feedback loop, increasing the release of gonadotropins, like luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which ultimately signals the testes to produce testosterone.¹
In men with low testosterone, Enclomiphene’s action is beneficial, especially for those with secondary hypogonadism, where testosterone levels are suppressed due to issues with the HPG axis. By promoting natural testosterone production, Enclomiphene maintains the body’s hormonal balance, providing a natural alternative to testosterone replacement therapy.
Therapeutic Uses of Enclomiphene Citrate
Male Infertility: Enclomiphene Citrate is often used in reproductive medicine to help men with fertility issues tied to low testosterone. By increasing testosterone, Enclomiphene can improve sperm quality and quantity, benefiting those dealing with infertility related to low sperm count or quality.²
Secondary Hypogonadism: For men with secondary hypogonadism, Enclomiphene offers a unique advantage over direct testosterone therapy by encouraging the body’s own testosterone production without suppressing natural hormone pathways.
Fertility Treatments and Other Benefits: Unlike some treatments, Enclomiphene promotes a balanced hormonal profile by naturally boosting testosterone levels rather than introducing external hormones. Research also explores potential benefits in other areas, such as anti-aging and treating gynecomastia (enlarged male breast tissue).
Administration and Dosage
Enclomiphene is taken orally, with results often seen within a few weeks. The exact timing varies depending on factors like age, baseline testosterone levels, and individual response to the medication. For best results, it’s crucial to follow the prescribed dosage and schedule consistently.
How Long Does It Take to Work?
Typically, Enclomiphene begins to work within a few weeks to a few months, with effects on low testosterone symptoms like energy, mood, and libido. Consistent use, along with open communication with your healthcare provider, will help monitor progress and make any necessary adjustments.
Side Effects
Most users experience mild side effects, including hot flashes, headaches, mood swings, and changes in libido. These usually diminish as the body adjusts. However, Enclomiphene should be used cautiously in people with liver conditions, and a thorough health evaluation is recommended before starting treatment.³
Conclusion
Enclomiphene Citrate shows promise as a natural, effective treatment for male infertility and low testosterone due to secondary hypogonadism. It supports fertility while providing a balanced approach to hormone regulation, setting it apart from traditional testosterone replacement therapies. With ongoing research, Enclomiphene may reveal even more benefits in fields like anti-aging and the management of gynecomastia.
As always, consult with a healthcare professional to ensure this treatment aligns with your health needs and goals.
Where Can You Get Enclomiphene Citrate treatment?
Interested in exploring Progesterone and Estradiol for reproductive health? Speak with our healthcare provider to see if it's the right option for you. For more information, visit agemd.com today!
Sources :
Working : Wiehle, R., Cunningham, G. R., Pitteloud, N., Wike, J., Hsu, K., Fontenot, G. K., Rosner, M., Dwyer, A., & Podolski, J. (2013). Testosterone restoration using enclomiphene citrate in men with secondary hypogonadism: a pharmacodynamic and pharmacokinetic study. BJU International, 112(8), 1188–1200. https://doi.org/10.1111/bju.12363
Therapeutic Uses : Ronald D. Wiehle, Gregory K. Fontenot, Jenny Wike, Kuang Hsu, Jennifer Nydell, Larry Lipshultz, Enclomiphene citrate stimulates testosterone production while preventing oligospermia: a randomized phase II clinical trial comparing topical testosterone, Fertility and Sterility,Volume 102, Issue 3,2014,Pages 720-727,ISSN 0015-0282, https://doi.org/10.1016/j.fertnstert.2014.06.004.
Side effects : Rodriguez, K. M., Pastuszak, A. W., & Lipshultz, L. I. (2016). Enclomiphene citrate for the treatment of secondary male hypogonadism. Expert Opinion on Pharmacotherapy, 17(11), 1561–1567. https://doi.org/10.1080/14656566.2016.1204294
Current version
Nov 26, 2024
Written by
Eileen Quinones (Certified Family Nurse Practitioner)
Fact checked by
Dr. Joel Lopez (MD, CNS, DABAARM)
Balance your hormones
with Enclomiphene or Progesterone
Fill out a quick form to share your
medical history, helping us tailor the
perfect plan for you.
Enclomiphene Citrate: Everything You Need to Know
Enclomiphene Citrate
Eileen Quinones
•
6 mins
• Nov 26, 2024
Enclomiphene Citrate is gaining recognition as an effective treatment for male infertility and low testosterone levels, particularly in men suffering from secondary hypogonadism. Unlike traditional testosterone replacement therapy, which introduces external hormones into the body, Enclomiphene works by stimulating the body’s natural testosterone production. This makes it an attractive option for men seeking to preserve fertility while addressing hormonal imbalances.
In this article, we will explore how Enclomiphene Citrate works, its therapeutic uses, the administration and dosage guidelines, as well as potential side effects. Whether you're dealing with male infertility, low testosterone, or secondary hypogonadism, Enclomiphene offers a unique, non-steroidal alternative to conventional treatments. Keep reading to learn more about how this medication can help restore your hormonal health and overall well-being.
What is Enclomiphene Citrate?
Enclomiphene Citrate is a selective estrogen receptor modulator (SERM) similar to Clomiphene Citrate, commonly known for treating male infertility. Specifically, it helps men with low testosterone due to hypogonadotropic hypogonadism—a condition where the brain’s hypothalamus or pituitary gland doesn’t stimulate testosterone production effectively. This non-steroidal medication, part of the SERM family, encourages testosterone production naturally, preserving fertility while boosting hormone levels.
How Does Enclomiphene Citrate Work?
Enclomiphene works by blocking estrogen’s effects in the brain, stimulating the hypothalamic-pituitary-gonadal (HPG) axis. When estrogen levels are high, the hypothalamus and pituitary gland reduce the hormones that encourage testosterone production. Enclomiphene interferes with this feedback loop, increasing the release of gonadotropins, like luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which ultimately signals the testes to produce testosterone.¹
In men with low testosterone, Enclomiphene’s action is beneficial, especially for those with secondary hypogonadism, where testosterone levels are suppressed due to issues with the HPG axis. By promoting natural testosterone production, Enclomiphene maintains the body’s hormonal balance, providing a natural alternative to testosterone replacement therapy.
Therapeutic Uses of Enclomiphene Citrate
Male Infertility: Enclomiphene Citrate is often used in reproductive medicine to help men with fertility issues tied to low testosterone. By increasing testosterone, Enclomiphene can improve sperm quality and quantity, benefiting those dealing with infertility related to low sperm count or quality.²
Secondary Hypogonadism: For men with secondary hypogonadism, Enclomiphene offers a unique advantage over direct testosterone therapy by encouraging the body’s own testosterone production without suppressing natural hormone pathways.
Fertility Treatments and Other Benefits: Unlike some treatments, Enclomiphene promotes a balanced hormonal profile by naturally boosting testosterone levels rather than introducing external hormones. Research also explores potential benefits in other areas, such as anti-aging and treating gynecomastia (enlarged male breast tissue).
Administration and Dosage
Enclomiphene is taken orally, with results often seen within a few weeks. The exact timing varies depending on factors like age, baseline testosterone levels, and individual response to the medication. For best results, it’s crucial to follow the prescribed dosage and schedule consistently.
How Long Does It Take to Work?
Typically, Enclomiphene begins to work within a few weeks to a few months, with effects on low testosterone symptoms like energy, mood, and libido. Consistent use, along with open communication with your healthcare provider, will help monitor progress and make any necessary adjustments.
Side Effects
Most users experience mild side effects, including hot flashes, headaches, mood swings, and changes in libido. These usually diminish as the body adjusts. However, Enclomiphene should be used cautiously in people with liver conditions, and a thorough health evaluation is recommended before starting treatment.³
Conclusion
Enclomiphene Citrate shows promise as a natural, effective treatment for male infertility and low testosterone due to secondary hypogonadism. It supports fertility while providing a balanced approach to hormone regulation, setting it apart from traditional testosterone replacement therapies. With ongoing research, Enclomiphene may reveal even more benefits in fields like anti-aging and the management of gynecomastia.
As always, consult with a healthcare professional to ensure this treatment aligns with your health needs and goals.
Where Can You Get Enclomiphene Citrate treatment?
Interested in exploring Progesterone and Estradiol for reproductive health? Speak with our healthcare provider to see if it's the right option for you. For more information, visit agemd.com today!
Current version
Nov 26, 2024
Written by
Eileen Quinones (Certified Family Nurse Practitioner)
Fact checked by
Dr. Joel Lopez (MD, CNS, DABAARM)
Balance your hormones
with Enclomiphene or Progesterone
Fill out a quick form to share your
medical history, helping us tailor the
perfect plan for you.
Balance your hormones
with Enclomiphene or Progesterone
Fill out a quick form to share your
medical history, helping us tailor the
perfect plan for you.
Sources :
Working : Wiehle, R., Cunningham, G. R., Pitteloud, N., Wike, J., Hsu, K., Fontenot, G. K., Rosner, M., Dwyer, A., & Podolski, J. (2013). Testosterone restoration using enclomiphene citrate in men with secondary hypogonadism: a pharmacodynamic and pharmacokinetic study. BJU International, 112(8), 1188–1200. https://doi.org/10.1111/bju.12363
Therapeutic Uses : Ronald D. Wiehle, Gregory K. Fontenot, Jenny Wike, Kuang Hsu, Jennifer Nydell, Larry Lipshultz, Enclomiphene citrate stimulates testosterone production while preventing oligospermia: a randomized phase II clinical trial comparing topical testosterone, Fertility and Sterility,Volume 102, Issue 3,2014,Pages 720-727,ISSN 0015-0282, https://doi.org/10.1016/j.fertnstert.2014.06.004.
Side effects : Rodriguez, K. M., Pastuszak, A. W., & Lipshultz, L. I. (2016). Enclomiphene citrate for the treatment of secondary male hypogonadism. Expert Opinion on Pharmacotherapy, 17(11), 1561–1567. https://doi.org/10.1080/14656566.2016.1204294